Original function is
.
Replace x = 4 in original function.
\
Evaluate powers:
.

(Multiply:
)
Apply commutative property of addition: a + b = b + a.
\
(Add: 256 + 32 = 288)
(Subtract:
)
(Subtract:
)
Replace x =
2 in original function.

(Evaluate power:
)
(Multiply:
)
(Add: 16 + 56 = 72)
(Subtract:
)
(Subtract:
)
, and
.